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46 2007

Journal of Food and Nutrition Research
Súhrny čísla 1 / 2007

KUKUROVÁ, I. - HOZOVÁ, B.
The utilization of disk diffusion method and the Delvotest® for determining synergistic effects of cephalosporin combinations in milk
Journal of Food and Nutrition Research, 46, 2007, č. 1, s. 9-14

Iveta Kukurová, Slovak University of Technology, Faculty of Chemical and Food Technology, Department of Nutrition and Food Evaluation, Radlinského 9, SK-812 37 Bratislava 1, Slovakia. E-mail: iveta@kukura.ca

Súhrn: Antibiotics including ß-lactam antibiotics are used in veterinary practice for the treatment of mastitis in milking cows. This study suggests that a suitable combination of antibiotics may result in synergistic action that might cause reduction of dosages with subsequent decrease in the maximum residue limits (MRL) as specified by the European Economic Commission of the European Union and the United States Food and Drug Administration recommendations. This study used disk diffusion assay and tested various combinations of 6 cephalosporins (cefuroxime, cefamandole, cefazoline, cefoperazone, cefotaxime and ceftazidime) for synergistic activity. Two of the antibiotic combinations were also tested by means of Delvotest® (The SP kit). In our model experiments with milk, an increase in antimicrobial activity indicating synergistic effect between tested cephalosporins was observed.

Kľúčové slová: cephalosporins; Delvostest SP; disk diffusion method; milk; synergistic effect

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