Vedecký časopis

Journal of Food and Nutrition Research
Online First Articles

Stanić, Z.
Improving therapeutic effects of curcumin – a review

Zorka Stanić, Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanović 12, P.O. Box 60, 34000 Kragujevac, Serbia. E-mail: zorkas@kg.ac.rs

Received 7 August 2017; 1st revised 18 October 2017; 2nd revised 20 December 2017; accepted 22 December 2017

Súhrn: Curcumin, a naturally occurring polyphenol isolated from the rhizomes of Curcuma longa and widely used as a colouring agent and spice in many food items, is well-known in the scientific community as a simple molecule exhibiting multiple therapeutic, anti-inflammatory and anticancer properties. Its ability to overcome multidrug resistance in different cancer cell types provides a starting point for its implementation as a therapeutic agent. The application of nanomaterials as drug-carriers improves the solubility of this therapeutic drug and its accumulation at tumor sites. The current article reviews the pharmacology of curcumin with its general chemical and therapeutic features and provides additional evidence to support the improvement of its pharmacological effects.

Kľúčové slová: curcumin; curcumin derivatives; synergy; antioxidant; chemoprevention; anticancer